Abstract
This report describes one case of verified treatment failure of pharyngeal gonorrhoea using ceftriaxone in Sweden. Previous reports described verified treatment failure of urogenital gonorrhoea using the internationally recommended first-line drug cefixime, but not with ceftriaxone, the last remaining option for empirical treatment of gonorrhoea. Enhanced awareness of clinical failures, pharmacodynamic considerations, follow-up and test of cure, adherence to appropriate case management and treatment guidelines as well as verification/falsification of presumed clinical treatment failures should be emphasised worldwide.
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Ceftriaxone / therapeutic use*
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Dose-Response Relationship, Drug
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Drug Resistance, Bacterial
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Gonorrhea / diagnosis
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Gonorrhea / drug therapy*
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Gonorrhea / microbiology
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Heterosexuality
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Humans
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Male
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Microbial Sensitivity Tests
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / genetics
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Neisseria gonorrhoeae / isolation & purification*
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Pharyngeal Diseases / diagnosis
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Pharyngeal Diseases / drug therapy*
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Pharyngeal Diseases / microbiology
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Polymerase Chain Reaction
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Practice Guidelines as Topic
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Sequence Analysis, DNA
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Sweden
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Treatment Failure
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Young Adult
Substances
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Anti-Bacterial Agents
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Ceftriaxone