Charge mapping in 3(10)-helical peptide chains by oxidation of the terminal ferrocenyl group

Org Lett. 2011 Mar 18;13(6):1282-5. doi: 10.1021/ol102864s. Epub 2011 Feb 22.

Abstract

Two series of 3(10)-helical peptides of different lengths and rigidity, based on the strongly foldameric α-aminoisobutyric acid and containing a terminal ferrocenyl unit, have been synthesized. Oxidation-state sensitive spectroscopic tags of helical peptides, the N-H groups, allowed mapping of the charge delocalization triggered by oxidation of the terminal ferrocenyl moiety and were monitored by IR spectroelectrochemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoisobutyric Acids / chemistry
  • Ferrous Compounds / chemistry*
  • Oxidation-Reduction
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Conformation
  • Protein Structure, Secondary
  • Spectrophotometry, Infrared

Substances

  • Aminoisobutyric Acids
  • Ferrous Compounds
  • Peptides
  • 2-aminoisobutyric acid