Biology-driven phase II trials: what is the optimal model for molecular selection?

MeSH terms

• Antineoplastic Agents / therapeutic use*
• Biological Assay
• Biomarkers, Tumor* / genetics
• Biomarkers, Tumor* / metabolism
• Clinical Trials, Phase II as Topic / methods*
• Genetic Testing
• High-Throughput Screening Assays*
• Humans
• Models, Biological*
• Molecular Targeted Therapy
• Neoplasms / drug therapy*
• Neoplasms / genetics
• Neoplasms / metabolism
• Patient Selection*
• Signal Transduction / drug effects*
• Signal Transduction / genetics
• Treatment Outcome