Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs

Angew Chem Int Ed Engl. 2011 Mar 1;50(10):2284-8. doi: 10.1002/anie.201006519. Epub 2011 Jan 31.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • Fluorine / chemistry*
  • Gene Silencing*
  • Nucleic Acid Conformation
  • Protein Structure, Tertiary
  • RNA, Small Interfering / chemistry*
  • RNA-Induced Silencing Complex / chemistry
  • Thermodynamics

Substances

  • RNA, Small Interfering
  • RNA-Induced Silencing Complex
  • Fluorine