8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment

Giuseppe Zagotto; Marco Redaelli; Riccardo Pasquale; Domenico D'Avella; Giorgio Cozza; Luca Denaro; Francesca Pizzato; Carla Mucignat-Caretta

doi:10.1016/j.bmcl.2011.02.001

8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2079-82. doi: 10.1016/j.bmcl.2011.02.001. Epub 2011 Feb 24.

Authors

Giuseppe Zagotto¹, Marco Redaelli, Riccardo Pasquale, Domenico D'Avella, Giorgio Cozza, Luca Denaro, Francesca Pizzato, Carla Mucignat-Caretta

Affiliation

¹ Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. [email protected]

PMID: 21353776
DOI: 10.1016/j.bmcl.2011.02.001

Abstract

Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Brain Neoplasms / pathology*
Glioblastoma / pathology*
Humans
Naphthalenes / chemistry
Naphthalenes / pharmacology*

Substances

Naphthalenes