Association between the SLC6A12 gene and negative symptoms of schizophrenia in a Korean population

Hae Jeong Park; Jong Woo Kim; Seo Kyung Lee; Su Kang Kim; Jin Kyung Park; Ah Rang Cho; Joo-Ho Chung; Ji Young Song

doi:10.1016/j.psychres.2011.01.023

Association between the SLC6A12 gene and negative symptoms of schizophrenia in a Korean population

Psychiatry Res. 2011 Oct 30;189(3):478-9. doi: 10.1016/j.psychres.2011.01.023. Epub 2011 Mar 2.

Authors

Hae Jeong Park¹, Jong Woo Kim, Seo Kyung Lee, Su Kang Kim, Jin Kyung Park, Ah Rang Cho, Joo-Ho Chung, Ji Young Song

Affiliation

¹ Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. [email protected]

PMID: 21367462
DOI: 10.1016/j.psychres.2011.01.023

Abstract

We investigated the association of single nucleotide polymorphisms of solute carrier family 6 member 11 (SLC6A11) (rs2304725, rs2272400, and rs2245532), SLC6A12 (rs216250 and rs557881) and SLC6A13 (rs2289954) with schizophrenia and its clinical symptoms. We found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carrier Proteins / genetics*
Female
GABA Plasma Membrane Transport Proteins
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Psychiatric Status Rating Scales
Republic of Korea
Schizophrenia / genetics*
Schizophrenia / physiopathology*

Substances

Carrier Proteins
GABA Plasma Membrane Transport Proteins
betaine plasma membrane transport proteins