Mediator: the missing link in amyloid precursor protein nuclear signalling

Anthony J Turner; Nikolai D Belyaev; Natalia N Nalivaeva

doi:10.1038/embor.2011.25

Mediator: the missing link in amyloid precursor protein nuclear signalling

EMBO Rep. 2011 Mar;12(3):180-1. doi: 10.1038/embor.2011.25.

Authors

Anthony J Turner¹, Nikolai D Belyaev, Natalia N Nalivaeva

Affiliation

¹ Institute of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. [email protected]

Abstract

Treatments for Alzheimer Disease remain limited. Have we finally found the missing link in the chain from disease initiation to cognitive decline and death?

Publication types

Comment

MeSH terms

Alzheimer Disease / genetics
Alzheimer Disease / metabolism
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism
Amyloid beta-Protein Precursor / chemistry
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism*
Cell Nucleus / metabolism*
Gene Expression Regulation*
Humans
Mediator Complex / genetics
Mediator Complex / metabolism*
Signal Transduction*

Substances

APP protein, human
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
MED12 protein, human
Mediator Complex