Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Mariko Kitajima; Masumi Iwai; Ruri Kikura-Hanajiri; Yukihiro Goda; Mitsuru Iida; Hisatoshi Yabushita; Hiromitsu Takayama

doi:10.1016/j.bmcl.2011.02.036

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. doi: 10.1016/j.bmcl.2011.02.036. Epub 2011 Feb 13.

Authors

Mariko Kitajima¹, Masumi Iwai, Ruri Kikura-Hanajiri, Yukihiro Goda, Mitsuru Iida, Hisatoshi Yabushita, Hiromitsu Takayama

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

PMID: 21376588
DOI: 10.1016/j.bmcl.2011.02.036

Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Discovery*
Indole Alkaloids / chemistry
Indole Alkaloids / pharmacology*
Molecular Structure
Plant Extracts / pharmacology
Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
Spectrometry, Mass, Electrospray Ionization
Voacanga / chemistry

Substances

Indole Alkaloids
Plant Extracts
Receptor, Cannabinoid, CB1