Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2795-8. doi: 10.1002/anie.201005280. Epub 2011 Feb 23.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyl Carrier Protein / genetics
  • Acyl Carrier Protein / metabolism*
  • Biosynthetic Pathways
  • Cyclopropanes / chemistry
  • Cyclopropanes / metabolism*
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / genetics
  • Multigene Family
  • Polyketide Synthases / metabolism
  • Thiazoles / chemistry
  • Thiazoles / metabolism*

Substances

  • Acyl Carrier Protein
  • Cyclopropanes
  • Multienzyme Complexes
  • Thiazoles
  • curacin A
  • Polyketide Synthases