Size dependent macrophage responses and toxicological effects of Ag nanoparticles

Jeongsin Park; Dae-Hyoun Lim; Hyun-Jeong Lim; Taejung Kwon; Jin-sil Choi; Sohee Jeong; In-Hong Choi; Jinwoo Cheon

doi:10.1039/c1cc10357a

Size dependent macrophage responses and toxicological effects of Ag nanoparticles

Chem Commun (Camb). 2011 Apr 21;47(15):4382-4. doi: 10.1039/c1cc10357a. Epub 2011 Mar 10.

Authors

Jeongsin Park¹, Dae-Hyoun Lim, Hyun-Jeong Lim, Taejung Kwon, Jin-sil Choi, Sohee Jeong, In-Hong Choi, Jinwoo Cheon

Affiliation

¹ Department of Microbiology, College of Medicine, Yonsei University, Seongsanno 250, Seodaemun-gu, Seoul, 120-752, Korea.

PMID: 21390403
DOI: 10.1039/c1cc10357a

Abstract

The immune-response of macrophages is an important area of investigation since it represents the major pathway by which early-stage defense barriers are established in skin, lungs, and mucosal systems to counteract foreign objects. In this study, we have examined the size-dependent inflammatory and toxicological effects of nanostructured silver particles (nano-Ag) on macrophage immune cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Humans
Inflammation / chemically induced
Inflammation / metabolism
Interleukin-8 / biosynthesis
Macrophages / drug effects*
Macrophages / immunology
Macrophages / metabolism
Metal Nanoparticles / chemistry*
Metal Nanoparticles / toxicity*
Particle Size*
Phagocytosis / drug effects
Phagocytosis / immunology
Reactive Oxygen Species / metabolism
Silver / chemistry*
Silver / toxicity*

Substances

Interleukin-8
Reactive Oxygen Species
Silver