Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure

ChemMedChem. 2011 Apr 4;6(4):617-22. doi: 10.1002/cmdc.201100107. Epub 2011 Mar 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Products / chemical synthesis
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Cell Cycle / drug effects
  • Dual-Specificity Phosphatases / antagonists & inhibitors*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Inhibitory Concentration 50
  • Mice
  • Molecular Mimicry
  • NIH 3T3 Cells
  • Phosphates / chemistry*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
  • Vaccinia virus / drug effects*
  • Vaccinia virus / growth & development
  • Vaccinia virus / metabolism

Substances

  • Biological Products
  • Enzyme Inhibitors
  • Phosphates
  • Dual-Specificity Phosphatases