Abstract
We performed a molecular epidemiologic survey of mutations associated with drug-resistance genes in Plasmodium falciparum in northeastern Myanmar. In this region, 3 highly mutated drug-resistance haplotypes and 1 associated with decreased quinine susceptibility were prevalent, which suggests that parasites may be resistant to multiple commonly used antimalarial drugs.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / pharmacology*
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Drug Resistance, Multiple / genetics*
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Genotype
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Haplotypes
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Humans
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / epidemiology*
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Malaria, Falciparum / parasitology
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Molecular Epidemiology*
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Mutation
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Myanmar / epidemiology
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects
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Plasmodium falciparum / genetics*
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Prevalence
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Protozoan Proteins / chemistry
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Protozoan Proteins / genetics
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Quinine / pharmacology
Substances
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Antimalarials
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Protozoan Proteins
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Quinine