Abstract
We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.
Published by Elsevier Masson SAS.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Acute Disease
-
Alkaloids / chemical synthesis
-
Alkaloids / chemistry
-
Alkaloids / pharmacology*
-
Animals
-
Carbolines / chemical synthesis
-
Carbolines / chemistry
-
Carbolines / pharmacology*
-
Cell Survival / drug effects
-
Extremities / blood supply*
-
Extremities / pathology
-
Free Radical Scavengers / metabolism
-
Ischemia / drug therapy*
-
Ischemia / pathology
-
Molecular Dynamics Simulation
-
Molecular Structure
-
PC12 Cells
-
Peptides / chemical synthesis
-
Peptides / chemistry
-
Peptides / pharmacology*
-
Rats
-
Reperfusion Injury / drug therapy*
-
Reperfusion Injury / pathology
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Alkaloids
-
Carbolines
-
Free Radical Scavengers
-
Peptides