Abstract
The vpr product of the human immunodeficiency virus type 1 (HIV-1) acts in trans to accelerate virus replication and cytopathic effect in T cells. Here it is shown that the HIV-1 viral particle contains multiple copies of the vpr protein. The vpr product is the first regulatory protein of HIV-1 to be found in the virus particle. This observation raises the possibility that vpr acts to facilitate the early steps of infection before de novo viral protein synthesis occurs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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CD4 Antigens / analysis
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Codon / genetics
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Gene Products, vpr
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Genes, Viral*
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Genotype
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HIV-1 / genetics*
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HIV-1 / metabolism
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HIV-1 / physiology
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Humans
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Molecular Weight
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Restriction Mapping
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Retroviridae Proteins / genetics
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Retroviridae Proteins / isolation & purification
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Retroviridae Proteins / metabolism*
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T-Lymphocytes / immunology
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Trans-Activators / metabolism*
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Transfection
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Virion / genetics*
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Virion / metabolism
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Virus Replication
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vpr Gene Products, Human Immunodeficiency Virus
Substances
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CD4 Antigens
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Codon
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Gene Products, vpr
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Retroviridae Proteins
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Trans-Activators
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vpr Gene Products, Human Immunodeficiency Virus