Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

Chem Commun (Camb). 2011 Apr 28;47(16):4667-9. doi: 10.1039/c1cc10172b. Epub 2011 Mar 15.

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Gadolinium / chemistry*
  • Liposomes / chemistry*
  • Magnetic Resonance Imaging*
  • Magnetics
  • Molecular Probes / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Protons

Substances

  • Contrast Media
  • Liposomes
  • Molecular Probes
  • Organometallic Compounds
  • Protons
  • Gadolinium