Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties

Hui He; Pui-Chi Lo; Sin-Lui Yeung; Wing-Ping Fong; Dennis K P Ng

doi:10.1039/c1cc10727e

Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties

Chem Commun (Camb). 2011 Apr 28;47(16):4748-50. doi: 10.1039/c1cc10727e. Epub 2011 Mar 15.

Authors

Hui He¹, Pui-Chi Lo, Sin-Lui Yeung, Wing-Ping Fong, Dennis K P Ng

Affiliation

¹ Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China.

PMID: 21409245
DOI: 10.1039/c1cc10727e

Abstract

A series of unsymmetrical distyryl BODIPYs have been prepared which function as highly potent photosensitisers with in vitro IC(50) values as low as 15 nM. Their cellular uptake, subcellular localisation and photocytotoxicity depend greatly on the styryl substituents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds / chemical synthesis*
Boron Compounds / chemistry
Boron Compounds / pharmacology*
Cell Line
Cell Survival / drug effects
Humans
Molecular Structure
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Styrenes / chemistry*

Substances

Boron Compounds
Photosensitizing Agents
Styrenes