Abstract
Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Breast / anatomy & histology
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Female
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Humans
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Image Processing, Computer-Assisted / methods
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Image Processing, Computer-Assisted / statistics & numerical data
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Male
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Microscopy / instrumentation
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Microscopy / methods*
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Prostatic Neoplasms / pathology
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Spectroscopy, Fourier Transform Infrared / instrumentation
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Spectroscopy, Fourier Transform Infrared / methods*
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Spectroscopy, Fourier Transform Infrared / statistics & numerical data
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Staining and Labeling
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Synchrotrons*