Development of a dosimetry inter-comparison for IMRT as part of site credentialing for a TROG multi-centre clinical trial for prostate cancer

Australas Phys Eng Sci Med. 2011 Jun;34(2):195-202. doi: 10.1007/s13246-011-0063-7. Epub 2011 Mar 22.

Abstract

A methodology has been developed for a dosimetry inter-comparison of intensity modulated radiation therapy (IMRT) delivery in Australasia. The inter-comparison is part of site credentialing for those sites participating in the prostate fractionated irradiation trial (PROFIT) for intermediate-risk prostate patients developed by the Ontario Clinical Oncology Group and coordinated in Australasia by the Trans Tasman Radiation Oncology Group. Features of the dosimetry inter-comparison design included the use of a dedicated pelvic anthropomorphic phantom, the use of a single CT data set of the phantom including contours and the use of radiochromic film as a dosimeter. Action levels for agreement between measured dose and treatment planning system dose have been proposed based on measurement uncertainty and international experience. A trial run of the dosimetry procedure at the reference centre gave results within the predefined action levels.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Australasia
  • Humans
  • Male
  • Multicenter Studies as Topic / methods
  • Multicenter Studies as Topic / standards
  • Phantoms, Imaging
  • Prostatic Neoplasms / radiotherapy*
  • Radiometry / instrumentation
  • Radiometry / methods
  • Radiometry / standards*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted / instrumentation
  • Radiotherapy Planning, Computer-Assisted / methods
  • Radiotherapy Planning, Computer-Assisted / standards*
  • Radiotherapy, Intensity-Modulated / instrumentation
  • Radiotherapy, Intensity-Modulated / methods
  • Radiotherapy, Intensity-Modulated / standards*
  • Randomized Controlled Trials as Topic / methods
  • Randomized Controlled Trials as Topic / standards
  • Reproducibility of Results
  • Tomography, X-Ray Computed