[Chorionic villi sampling: experience of the initial 500 samples]

C Donner; P Simon; F Gosselin; E Vamos; P Cochaux; G Vassart; F Rodesch

[Chorionic villi sampling: experience of the initial 500 samples]

Rev Med Brux. 1990 Jun;11(6):211-5.

[Article in French]

Authors

C Donner¹, P Simon, F Gosselin, E Vamos, P Cochaux, G Vassart, F Rodesch

Affiliation

¹ Laboratoire de cytogénétique, Hôpital Universitaire Brugmann.

PMID: 2142535

Abstract

We report our experience in first trimester antenatal diagnosis since 1984. Transcervical chorionic villus sampling (CVS) was performed in 498 pregnancies. The rate of abnormal pregnancies was 6%, the rate of chromosomal abnormalities (trisomy) in the indication group "maternal age" was 2%. The fetal loss rate (until 28 weeks) was 3.4% (17 cases), the procedure related loss plus the background loss was 2.4% (12 cases). For 92.8% of the patients a diagnosis was available after 1 CVS procedure. Ultimately an antenatal diagnosis was given to 99% of the women through a second CVS procedure or an amniocentesis or a cordocentesis. No maternal complication was observed.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Chorionic Villi Sampling*
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Down Syndrome / diagnosis*
Down Syndrome / genetics
Female
Fetal Diseases / diagnosis*
Fetal Diseases / genetics
Humans
Pregnancy
Trisomy