Lung cancer shows a tendency of higher incidence and higher mortality in recent years, but the overall 5-year survival rate is less than 15%. Serum tumor markers of lung cancer play an important role in early diagnosis, determining of pathology types, staging, evaluation of response, and prognosis of lung cancer. In this review, 6 most important markers were reviewed, including neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), cytokeratin 19 fragments (Cyfra 21-1), tissue polypeptide antigen (TPA), squamous cell carcinoma associated antigen (SCC-Ag), carcinoembryonic antigen (CEA).
肺癌血清肿瘤标志物在肺癌的早期诊断、病理分型、疾病分期、疗效评估和指导预后等方面起着重要的作用，本文旨在对神经元特异性烯醇化酶（NSE）、胃泌素释放肽（ProGRP）、细胞角蛋白19片段（CYFRA 21-1）、组织多肽抗原（TPA）、鳞状细胞癌相关抗原（SCC-Ag）和癌胚抗原（CEA）这6种重要的肺癌血清肿瘤标志物的临床意义进行综述。