Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity

Clin Infect Dis. 2011 Apr 1;52(7):925-8. doi: 10.1093/cid/cir072.

Abstract

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • HIV Infections / virology*
  • HIV-1 / physiology*
  • Humans
  • Receptors, CCR5 / metabolism
  • Receptors, CXCR4 / metabolism
  • Receptors, HIV / metabolism*
  • Viral Tropism*
  • Virology / methods*
  • Virus Attachment*

Substances

  • CXCR4 protein, human
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, HIV