Abstract
A new nor-ceanothane-type triterpenoid, breynceanothanolic acid (1), and seven novel 4α-methyl sterols, fruticosides A-G (2-8), were obtained from the roots of Breynia fruticosa. The new compound structures were established by means of extensive spectroscopic and chemical methods. Compounds 7 and 8 are sulfur-containing derivatives of the 4α-methyl sterols, and the sugar moiety of compounds 4, 5, 7, and 8 (L-quinovose) is uncommon in plants. Compounds 1 and 2 exhibited moderate cytotoxicity against five human cancer cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Euphorbiaceae / chemistry*
-
Female
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
HL-60 Cells
-
Humans
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Roots / chemistry
-
Sterols / chemistry
-
Sterols / isolation & purification*
-
Sterols / pharmacology
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology
Substances
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal
-
Glycosides
-
Sterols
-
Triterpenes
-
breynceanothanolic acid
-
ceanothane