Abstract
Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colleagues use a genetically susceptible mouse model to show that myocarditis is a T cell-mediated autoimmune disease that occurs due to insufficient thymic negative selection of α-myosin-reactive T cells.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Disease Models, Animal
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HLA-DQ Antigens / genetics
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Immune Tolerance*
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Mice
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Mice, Inbred NOD
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Mice, Transgenic
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Myocarditis / etiology
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Myocarditis / immunology*
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Myocarditis / prevention & control
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T-Lymphocytes / immunology
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Ventricular Myosins / immunology
Substances
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HLA-DQ Antigens
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HLA-DQ8 antigen
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Ventricular Myosins