Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity

J Allergy Clin Immunol. 2011 Jul;128(1):212-4. doi: 10.1016/j.jaci.2011.02.035. Epub 2011 Mar 24.

Abstract

Peanut sensitization in diacylglycerol kinase zeta (DGKζ) deficient mice led to elevated peanut-IgE levels and severe anaphylaxis. DGKζ deficient CD4+T cells did not account for the phenotype. Future studies will determine which immune lineage caused increased food hypersensitivity.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Diacylglycerol Kinase / deficiency*
  • Diacylglycerol Kinase / immunology
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Peanut Hypersensitivity / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Diacylglycerol Kinase
  • diacylglycerol kinase zeta, mouse