Mastocytosis and diffuse large B-cell lymphoma, an unlikely combination

Neth J Med. 2011 Mar;69(3):132-4.

Abstract

Systemic mastocytosis may be accompanied by a second haematological malignancy, usually of myeloid origin. However, a number of case reports describe systemic mastocytosis coexisting with a second haematological malignancy of lymphoid origin. Here, we report a case of a 74-year-old man with systemic mastocytosis who developed a diffuse large B-cell lymphoma. A short overview of the literature concerning mastocytosis accompanied by a second haematological malignancy is presented.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Murine-Derived / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Fatal Outcome
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / complications*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Male
  • Mastocytosis, Systemic / complications*
  • Mastocytosis, Systemic / drug therapy
  • Prednisolone / administration & dosage
  • Rituximab

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Rituximab
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone