Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time

Tieh-Kang Wu; Shan-Yang Lin; Hong-Liang Lin; Yu-Ting Huang

doi:10.1016/j.bmcl.2011.03.001

Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time

Bioorg Med Chem Lett. 2011 May 15;21(10):3148-51. doi: 10.1016/j.bmcl.2011.03.001. Epub 2011 Mar 4.

Authors

Tieh-Kang Wu¹, Shan-Yang Lin, Hong-Liang Lin, Yu-Ting Huang

Affiliation

¹ Department of Biotechnology, Yuanpei University, Hsin-Chu, Taiwan.

PMID: 21450466
DOI: 10.1016/j.bmcl.2011.03.001

Abstract

We first report that the formation of pharmaceutical co-crystal can be synchronously screened and confirmed by a simultaneous DSC-FTIR microspectroscopic system, in which this combined unique system giving spectroscopic and thermodynamic information could provide a easy and direct way for one step screening and qualitative detection of the co-crystal formation in real time.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calorimetry, Differential Scanning*
Crystallization
Molecular Structure
Spectroscopy, Fourier Transform Infrared*
Thermodynamics