Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative

H J Faber; H G Sprenger; J Weits

Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative

Neth J Med. 1990 Aug;37(1-2):69-74.

Authors

H J Faber¹, H G Sprenger, J Weits

Affiliation

¹ Department of Internal Medicine, State University Hospital Groningen.

PMID: 2145521

Abstract

This is a case report of a 31-yr-old homosexual male with AIDS, admitted to our clinic with a relapse P. carinii pneumonitis (PCP) and a previous history of severe adverse reactions to currently used therapy. He was treated successfully with trimetrexate (TMTX), a dihydrofolate reductase inhibitor combined with leucovorin rescue. Adverse reactions, current therapy and prophylaxis of PCP in AIDS are discussed.

Publication types

Case Reports

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
Adult
Folic Acid Antagonists / pharmacology
Folic Acid Antagonists / therapeutic use*
Humans
Male
Pneumonia, Pneumocystis / complications
Pneumonia, Pneumocystis / diagnostic imaging
Pneumonia, Pneumocystis / drug therapy*
Quinazolines / pharmacology
Quinazolines / therapeutic use*
Radiography
Recurrence
Trimetrexate

Substances

Folic Acid Antagonists
Quinazolines
Trimetrexate