Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection

Chem Commun (Camb). 2011 May 21;47(19):5506-8. doi: 10.1039/c1cc10849b. Epub 2011 Apr 1.

Abstract

This communication reports the synthesis, characterization and in vivo evaluation in mice of a new tri-tyrosine conjugated MR contrast agent, which may help to identify vulnerable plaques in atherosclerosis by targeting the lipid core.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis*
  • Contrast Media / chemistry
  • Dextrans / chemical synthesis*
  • Dextrans / chemistry
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Plaque, Atherosclerotic / diagnosis*
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemistry

Substances

  • Contrast Media
  • Dextrans
  • trityrosine
  • Tyrosine