Abstract
Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Apoptosis / drug effects
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Caspase 3 / metabolism
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Cell Line, Tumor
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / metabolism
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Colonic Neoplasms / pathology
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Drug Delivery Systems
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Fluorouracil / administration & dosage*
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Hydrogels / administration & dosage
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Linoleic Acids, Conjugated / administration & dosage
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Liver Neoplasms, Experimental / drug therapy
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Liver Neoplasms, Experimental / secondary
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Mice
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Mice, Inbred BALB C
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Nanotechnology
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Peritoneal Neoplasms / drug therapy
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Peritoneal Neoplasms / secondary
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Poloxamer / administration & dosage
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Proto-Oncogene Proteins c-bcl-2 / metabolism
Substances
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Antineoplastic Agents
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Hydrogels
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Linoleic Acids, Conjugated
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Proto-Oncogene Proteins c-bcl-2
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Poloxamer
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Casp3 protein, mouse
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Caspase 3
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Fluorouracil