Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

Karem Shanab; Eva Schirmer; Eva Wulz; Barbara Weissenbacher; Sigrid Lassnig; Rita Slanz; Germana Fösleitner; Wolfgang Holzer; Helmut Spreitzer; Peter Schmidt; Babette Aicher; Gilbert Müller; Eckhard Günther

doi:10.1016/j.bmcl.2011.03.013

Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

Bioorg Med Chem Lett. 2011 May 15;21(10):3117-21. doi: 10.1016/j.bmcl.2011.03.013. Epub 2011 Mar 30.

Authors

Karem Shanab¹, Eva Schirmer, Eva Wulz, Barbara Weissenbacher, Sigrid Lassnig, Rita Slanz, Germana Fösleitner, Wolfgang Holzer, Helmut Spreitzer, Peter Schmidt, Babette Aicher, Gilbert Müller, Eckhard Günther

Affiliation

¹ Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

PMID: 21458262
DOI: 10.1016/j.bmcl.2011.03.013

Abstract

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Naphthoquinones / chemistry
Pyrroles / chemical synthesis*
Pyrroles / chemistry
Pyrroles / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Naphthoquinones
Pyrroles