Orofacial granulomatosis in children--a challenge for diagnosis and treatment

Kaija-Leena Kolho; Kaarina Heiskanen; Matti Verkasalo; Anne Pitkäranta

doi:10.1016/j.ijporl.2011.03.003

Orofacial granulomatosis in children--a challenge for diagnosis and treatment

Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):864-7. doi: 10.1016/j.ijporl.2011.03.003. Epub 2011 Apr 1.

Authors

Kaija-Leena Kolho¹, Kaarina Heiskanen, Matti Verkasalo, Anne Pitkäranta

Affiliation

¹ Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Faculty of Medicine, Helsinki, Finland. [email protected]

PMID: 21458863
DOI: 10.1016/j.ijporl.2011.03.003

Abstract

The data on orofacial granulomatosis, OFG, in children are sparse. We describe here 8 pediatric patients presenting with OFG, 2 of these cases associating with Crohn's disease. Therapeutic agents included systemic immunosuppressants such as glucocorticoids, methotrexate, anti-TNF-alpha agent, dapsone, antibiotics (metronidazole), and local treatment with topical tacrolimus or intralesional injections of triamcinolone hexacetonide. The treatment response ranged from good to poor results. The number of young patients suffering from OFG is not currently known and there are no gold standards for treatment. Thus, prospective follow-up studies on these patients are needed to gain more experience of the therapeutic responses.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Female
Granulomatosis, Orofacial / diagnosis*
Granulomatosis, Orofacial / etiology
Granulomatosis, Orofacial / therapy*
Humans
Male