Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity

Madhumita Mandal; Deepak Kumar; Rajneeta Roy; Rupashree Sen; Padma Das; Mitali Chatterjee; Parasuraman Jaisankar

doi:10.1016/j.bmcl.2011.03.028

Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity

Bioorg Med Chem Lett. 2011 May 15;21(10):3084-7. doi: 10.1016/j.bmcl.2011.03.028. Epub 2011 Mar 16.

Authors

Madhumita Mandal¹, Deepak Kumar, Rajneeta Roy, Rupashree Sen, Padma Das, Mitali Chatterjee, Parasuraman Jaisankar

Affiliation

¹ Department of Chemistry, Indian Institute of Chemical Biology (Unit of C.S.I.R), 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India.

PMID: 21459575
DOI: 10.1016/j.bmcl.2011.03.028

Abstract

2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC(50) of 13.0-17.0 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / toxicity*
Cell Line, Tumor
Cell Survival / drug effects
Crystallography, X-Ray
Ethylenes / chemical synthesis*
Ethylenes / chemistry
Ethylenes / pharmacology*
Flow Cytometry
Humans
Indoles / chemistry*
Inhibitory Concentration 50
Molecular Structure

Substances

Antineoplastic Agents
Ethylenes
Indoles
ethylene