Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson's disease

C W Hicks; M M Pandya; I Itin; H H Fernandez

doi:10.1016/j.parkreldis.2011.03.003

Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson's disease

Parkinsonism Relat Disord. 2011 Jun;17(5):379-81. doi: 10.1016/j.parkreldis.2011.03.003. Epub 2011 Apr 2.

Authors

C W Hicks¹, M M Pandya, I Itin, H H Fernandez

Affiliation

¹ Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.

PMID: 21459656
DOI: 10.1016/j.parkreldis.2011.03.003

Abstract

Impulse-control disorders (ICDs) are becoming more commonly recognized in the Parkinson disease (PD) population. To date, there are no definitive methods of treating dopamine dysregulation syndromes in PD patients. We sought to uncover an effective treatment option for future study. We report a series of 3 PD patients with ICDs who were effectively treated with valproate. Based on these encouraging preliminary observations, future controlled clinical trials investigating the efficacy of valproate for ICDs in PD are recommended.

Publication types

Case Reports

MeSH terms

Adult
Anticonvulsants / therapeutic use*
Antiparkinson Agents / adverse effects
Disruptive, Impulse Control, and Conduct Disorders / chemically induced
Disruptive, Impulse Control, and Conduct Disorders / drug therapy*
Humans
Levodopa / adverse effects
Male
Middle Aged
Parkinson Disease / drug therapy
Valproic Acid / therapeutic use*

Substances

Anticonvulsants
Antiparkinson Agents
Levodopa
Valproic Acid