HIV-1 drug resistance mutations among antiretroviral-naive HIV-1-infected patients in Asia: results from the TREAT Asia Studies to Evaluate Resistance-Monitoring Study

Clin Infect Dis. 2011 Apr 15;52(8):1053-7. doi: 10.1093/cid/cir107.

Abstract

Of 682 antiretroviral-naïve patients initiating antiretroviral therapy in a prospective, multicenter human immunodeficiency virus type 1 (HIV-1) drug resistance monitoring study involving 8 sites in Hong Kong, Malaysia, and Thailand, the prevalence of patients with ≥1 drug resistance mutation was 13.8%. Primary HIV drug resistance is emerging after rapid scaling-up of antiretroviral therapy use in Asia.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / pharmacology*
  • Drug Resistance, Viral*
  • Female
  • HIV Infections / epidemiology*
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Hong Kong / epidemiology
  • Humans
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Mutation, Missense*
  • Prevalence
  • Prospective Studies
  • Thailand / epidemiology

Substances

  • Anti-HIV Agents