Abstract
This randomized, double-blind study evaluated efficacy of a single-pill combination of amlodipine/valsartan (Aml/Val) in Asian patients with hypertension not responding to Val 80 mg. Patients with mean sitting diastolic blood pressure (DBP) ≥90-≤110 mmHg were randomized to Aml/Val 5/80, Val 80, or Val 160 mg for 8 weeks. At week-8 endpoint, significantly greater reductions in BP were seen with Aml/Val 5/80 mg than valsartan monotherapies (p < 0.0001). The BP control was greater with Aml/Val 5/80 (70.5%) than Val (44.1-58.6%) monotherapies. The combination was well tolerated. In conclusion, single-pill combination with Aml/Val provided significant additional BP reduction and control in hypertensive patients not responding to Val 80 mg.
Publication types
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Amlodipine / adverse effects
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Amlodipine / therapeutic use*
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Angiotensin II Type 1 Receptor Blockers / adverse effects
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Angiotensin II Type 1 Receptor Blockers / therapeutic use
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Antihypertensive Agents / adverse effects
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Antihypertensive Agents / therapeutic use*
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Asian People / ethnology*
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Calcium Channel Blockers / adverse effects
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Calcium Channel Blockers / therapeutic use
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China / epidemiology
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Double-Blind Method
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Drug Combinations
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Drug-Related Side Effects and Adverse Reactions
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Female
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Humans
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Hypertension / drug therapy*
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Hypertension / epidemiology
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Hypertension / ethnology*
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Korea / epidemiology
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Male
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Middle Aged
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Tetrazoles / adverse effects
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Tetrazoles / therapeutic use*
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Thailand / epidemiology
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Treatment Outcome
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Valine / adverse effects
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Valine / analogs & derivatives*
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Valine / therapeutic use
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Valsartan
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Young Adult
Substances
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Angiotensin II Type 1 Receptor Blockers
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Antihypertensive Agents
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Calcium Channel Blockers
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Drug Combinations
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Tetrazoles
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Amlodipine
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Valsartan
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Valine