Abstract
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.
Published by Elsevier Masson SAS.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Carbolines / chemistry*
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Edema / chemically induced
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Edema / prevention & control
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Male
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Mesenteric Arteries / drug effects*
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Mesenteric Arteries / pathology
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Mice
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Mice, Inbred ICR
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Models, Molecular
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Molecular Dynamics Simulation
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Molecular Structure
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Rats
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Rats, Wistar
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Reperfusion Injury / drug therapy*
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Reperfusion Injury / pathology
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Stereoisomerism
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Xylenes / antagonists & inhibitors
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Carbolines
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Oligopeptides
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Xylenes