Abstract
In a double-blind clinical study, electrocardiogram, blood pressure and systolic time intervals were measured in 40 depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. While amitriptyline significantly increased the heart rate, the QTc interval and the PEP/LVET ratio, paroxetine did not alter any of the cardiovascular parameters measured.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
MeSH terms
-
Adult
-
Amitriptyline / adverse effects
-
Amitriptyline / therapeutic use
-
Antidepressive Agents / adverse effects*
-
Antidepressive Agents / therapeutic use
-
Blood Pressure / drug effects
-
Double-Blind Method
-
Electrocardiography
-
Female
-
Heart Rate / drug effects
-
Hemodynamics / drug effects*
-
Humans
-
Male
-
Middle Aged
-
Paroxetine
-
Piperidines / adverse effects*
-
Piperidines / therapeutic use
Substances
-
Antidepressive Agents
-
Piperidines
-
Amitriptyline
-
Paroxetine