Abstract
In the present study we show that when certain major histocompatibility complex-alloreactive CD8+ T cell clones with natural killer-like activity are stimulated through their CD3 molecules, in the absence of significant cross-linkage (as provided by Fab' fragments of OKT3 antibodies) they lose their interleukin 2 response. This is attributable to an induction of a nonspecific autocytolytic activity. These results suggest that activation of this process in some cytotoxic cells leads to an overall decrease in CTL activity and constitutes a possible mechanism of suppression of the immune response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / physiology*
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Antigens, Differentiation, T-Lymphocyte / physiology*
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Autolysis
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CD3 Complex
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Calcium / physiology
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Cell Survival
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Clone Cells
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Cytotoxicity, Immunologic*
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Humans
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Immunity, Cellular
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In Vitro Techniques
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Interleukin-2 / pharmacology
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Killer Cells, Natural / immunology
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Lymphocyte Activation
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Receptors, Antigen, T-Cell / physiology*
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Signal Transduction
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD3 Complex
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Interleukin-2
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Receptors, Antigen, T-Cell
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Calcium