Abstract
This report is an open-label case series of seven depressed adolescents with bipolar disorder treated with uridine for 6 weeks. Treatment response was measured with the Children's Depression Rating Scale-Revised and the Clinical Global Impressions scale. Uridine was associated with decreased depressive symptoms, and was well tolerated by study participants. Further systematic studies of uridine are warranted.
MeSH terms
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Adolescent
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Antidepressive Agents / adverse effects
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Antidepressive Agents / pharmacology*
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Antidepressive Agents / therapeutic use
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Bipolar Disorder / drug therapy*
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Depression / drug therapy*
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Depressive Disorder / drug therapy*
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Female
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Humans
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Male
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Nucleosides / adverse effects
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Nucleosides / pharmacology
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Nucleosides / therapeutic use
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Pilot Projects
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Psychiatric Status Rating Scales
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Uridine / adverse effects
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Uridine / pharmacology*
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Uridine / therapeutic use
Substances
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Antidepressive Agents
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Nucleosides
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Uridine