Highly regio- and diastereoselective anionic [3 + 2] cycloaddition under phase transfer catalytic conditions

J Org Chem. 2011 May 20;76(10):4194-9. doi: 10.1021/jo2005268. Epub 2011 Apr 28.

Abstract

A highly trans and regioselective anionic formal [3 + 2] cycloaddition was achieved with allylic sulfones having an MBH acrylamide backbone under phase transfer organocatalytic conditions giving rise to the formation of unprecedented densely substituted cyclopentene derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamide / chemistry
  • Catalysis
  • Cyclopentanes / chemistry
  • Stereoisomerism
  • Substrate Specificity
  • Sulfones / chemistry*

Substances

  • Cyclopentanes
  • Sulfones
  • Acrylamide