Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins

Curr Opin Chem Biol. 2011 Jun;15(3):452-7. doi: 10.1016/j.cbpa.2011.03.014. Epub 2011 Apr 12.

Abstract

Computational and theoretical methods are advancing protein design as a means to create and investigate proteins. Such efforts further our capacity to control, design and understand biomolecular structure, sequence and function. Herein, the focus is on some recent applications that involve using theoretical and computational methods to guide the design of protein sequence ensembles, new enzymes, proteins with novel cofactors, and membrane proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Coenzymes / chemistry
  • Computational Biology / methods*
  • Enzymes / chemistry
  • Membrane Proteins / chemistry
  • Protein Engineering*
  • Proteins / chemistry*

Substances

  • Coenzymes
  • Enzymes
  • Membrane Proteins
  • Proteins