Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis

Otolaryngol Head Neck Surg. 2011 Jan;144(1):96-100. doi: 10.1177/0194599810390881.

Abstract

Objective: To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls.

Study design and setting: A case-control study.

Subjects and methods: Subjects (N = 214) were all adults (>20 years old) and were divided into patients with CRS (n = 106) and controls (n = 108). Five SNPs (rs1898830, rs3804099, rs3804100, R677W, and rs5743708) were selected and genotyped in a case-control study with the single-base-pair primer extension (SNaPshot) assay.

Results: The case-control study revealed that 2 SNPs in TLR2, rs3804099 (odds ratio [OR] = 2.88; 95% confidence interval [CI] = 1.17-7.09; P = .022) and rs3804100 (OR = 3.76; 95% CI = 1.42-9.96; P = .008), showed significant differences in minor allele frequency between CRS patients and controls. These 2 SNPs were correlated with CRS risk in Korean patients.

Conclusions: Two SNPs in TLR2 may be associated with increased risk of CRS in Korean subjects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Prevalence
  • Prospective Studies
  • RNA / genetics*
  • Republic of Korea / epidemiology
  • Rhinitis / epidemiology
  • Rhinitis / genetics*
  • Rhinitis / metabolism
  • Sinusitis / epidemiology
  • Sinusitis / genetics*
  • Sinusitis / metabolism
  • Toll-Like Receptor 2 / blood
  • Toll-Like Receptor 2 / genetics*

Substances

  • Toll-Like Receptor 2
  • RNA