The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

J Surg Oncol. 2011 Sep 1;104(3):323-32. doi: 10.1002/jso.21943. Epub 2011 Apr 14.

Abstract

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coloring Agents*
  • Contrast Media*
  • Fluorescent Dyes*
  • Humans
  • Indocyanine Green*
  • Neoplasms / diagnosis*
  • Neoplasms / surgery*
  • Surgery, Computer-Assisted*

Substances

  • Coloring Agents
  • Contrast Media
  • Fluorescent Dyes
  • Indocyanine Green