The epigenetics of Alzheimer's disease--additional considerations

Neurobiol Aging. 2011 Jul;32(7):1196-7. doi: 10.1016/j.neurobiolaging.2011.02.025. Epub 2011 Apr 16.

Abstract

The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Animals
  • DNA Methylation / genetics*
  • Epigenesis, Genetic / genetics*
  • Epigenesis, Genetic / physiology*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Molecular Biology / trends*
  • One-Carbon Group Transferases / genetics*
  • Translational Research, Biomedical / trends*

Substances

  • One-Carbon Group Transferases