T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison

Magn Reson Med. 2011 May;65(5):1407-15. doi: 10.1002/mrm.22716. Epub 2010 Dec 16.

Abstract

Quantitative T(1) mapping of delayed gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T(1) times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates, and patient specific delay times. In this work, a model driven approach to account for variations between patients to allow for comparison of T(1) data is provided. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above were used to normalize T(1) values to a matched state. Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state.

Trial registration: ClinicalTrials.gov NCT00360815 NCT00360893.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chi-Square Distribution
  • Contrast Media*
  • Diabetes Mellitus, Type 1 / pathology*
  • Female
  • Fibrosis / pathology
  • Gadolinium DTPA*
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Myocardium / pathology*

Substances

  • Contrast Media
  • Gadolinium DTPA

Associated data

  • ClinicalTrials.gov/NCT00360815
  • ClinicalTrials.gov/NCT00360893