Abstract
Morphological changes in the spinal cord of rats with different intensity of pathological symptoms were studied at the peak of the experimental encephalomyelitis development. Light-microscopical and immunohistochemical methods were used. Distribution of proliferating cell nuclear antigen (PCNA), astrocyte marker - glial fibrillar acidic protein (GFAP), and microglia and macrophage marker Iba-1, was studied. Heterogeneity in morphological manifestations of the experimental allergic encephalomyelitis was shown. Four typical patterns of morphological manifestations of the disease were demonstrated depending on the preferential involvement of pia mater, vessels, spinal cell nuclei or conductive tracts in the pathological process.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium-Binding Proteins / biosynthesis
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Calcium-Binding Proteins / immunology
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / metabolism
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Encephalomyelitis, Autoimmune, Experimental / pathology*
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Female
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Microfilament Proteins
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Myelitis / immunology
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Myelitis / metabolism
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Myelitis / pathology*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / immunology
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Proliferating Cell Nuclear Antigen / biosynthesis
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Proliferating Cell Nuclear Antigen / immunology
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Rats
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Rats, Wistar
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Spinal Cord / immunology
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Spinal Cord / metabolism
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Spinal Cord / pathology*
Substances
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Aif1 protein, rat
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Calcium-Binding Proteins
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Microfilament Proteins
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Nerve Tissue Proteins
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Proliferating Cell Nuclear Antigen