Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Carcinoma, Acinar Cell / pathology*
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Cell Line, Tumor
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Cell Movement / drug effects*
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Circular Dichroism
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Crystallography, X-Ray
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Depsipeptides / chemistry
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Depsipeptides / pharmacology*
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Fusarium / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neoplasm Invasiveness
Substances
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Antineoplastic Agents
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Depsipeptides
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fusaristatin A