Abstract
With recently developed spin label techniques for monitoring macromolecular rotational motion, heme-liganded sickle cell hemoglobin in the presence of inositol hexaphosphate is shown to exhibit restricted motional freedom as compared to liganded normal adult human hemoglobin. This motional restriction is dependent on both hemoglobin concentration and temperature.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Carboxyhemoglobin*
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Chemical Phenomena
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Chemistry
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Electron Spin Resonance Spectroscopy
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Hemoglobin, Sickle*
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Hemoglobins*
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Humans
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Ligands
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Mathematics
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Phytic Acid / pharmacology
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Rotation
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Spin Labels
Substances
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Hemoglobin, Sickle
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Hemoglobins
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Ligands
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Spin Labels
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Phytic Acid
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Carboxyhemoglobin