The clinico-epidemiological characteristics and therapy in 26 patients with infection produced by Listeria monocytogenes were reported. In 14 cases there was a primary bacteremia and in 12 patients there was a meningeal involvement. In 22 patients a previous disease was detected. Chronic immunosuppressor therapy was present in 13 cases. The most common symptom was the fever associated with meningeal syndrome, decreased consciousness and or focal neurologic involvement in cases with meningitis. In 76.9% of the patients the form of presentation was acute. Cerebrospinal fluid examination revealed an increased number of cells with a predominance of polymorphonuclear elements. Ampicillin and penicillin either single or associated with aminoglycosides were the most used antibiotics. The overall mortality was 30.8%.