Immunology: A helping hand against autoimmunity

Nature. 2011 Apr 28;472(7344):421-2. doi: 10.1038/472421a.

Abstract

The TH17 helper cells of the immune system have a dark side: they mediate autoimmune disorders. Two drugs that prevent the differentiation and activity of these cells might be of therapeutic value.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Autoimmunity / drug effects
  • Autoimmunity / immunology
  • Cell Differentiation / drug effects*
  • Digoxin / analogs & derivatives
  • Digoxin / metabolism
  • Digoxin / pharmacology*
  • Digoxin / therapeutic use
  • Interleukin-17 / biosynthesis
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism
  • Mice
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / antagonists & inhibitors*
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / metabolism
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / antagonists & inhibitors*
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism
  • Sulfonamides / pharmacology*
  • Th17 Cells / cytology*
  • Th17 Cells / drug effects*
  • Th17 Cells / immunology
  • Th17 Cells / metabolism
  • Thiazoles / pharmacology*

Substances

  • Interleukin-17
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Rora protein, mouse
  • SR1001
  • Sulfonamides
  • Thiazoles
  • Digoxin